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Laser Direct Writing of Thick Hybrid Polymers for Microfluidic Chips

机译:用于微流控芯片的厚混合聚合物的激光直接写入

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摘要

This work presents patterning of thick (10–50 µm) hybrid polymer structures of ORMOCER® by laser direct writing. ORMOCER® combine polymer-like fabrication processes with glass-like surface chemistry that is beneficial for many bio-microfluidic applications. ORMOCER® is liquid before exposure, so patterning is done by contact-free lithography, such as proximity exposure. With laser direct writing, we obtained higher resolution patterns, with smaller radius of curvature (~2–4 µm), compared to proximity exposure (~10–20 µm). Process parameters were studied to find the optimal dose for different exposure conditions and ORMOCER® layer thicknesses. Two fluidic devices were successfully fabricated: a directional wetting device (fluidic diode) and an electrophoresis chip. The fluidic diode chip operation depends on the sharp corner geometry and water contact angle, and both have been successfully tailored to obtain diodicity. Electrophoresis chips were used to separate of two fluorescent dyes, rhodamine 123 and fluorescein. The electrophoresis chip also made use of ORMOCER® to ORMOCER® bonding
机译:这项工作介绍了通过激光直接书写对厚厚(10–50 µm)的ORMOCER®杂化聚合物结构进行构图的方法。 ORMOCER®将类聚合物的制造工艺与类玻璃的表面化学相结合,这对许多生物微流体应用都是有益的。 ORMOCER®在曝光前为液态,因此构图是通过非接触式光刻(例如接近曝光)完成的。与邻近曝光(〜10–20 µm)相比,使用激光直接写入,我们获得了更高分辨率的图案,并且曲率半径(〜2-4 µm)更小。研究了工艺参数以找到针对不同暴露条件和ORMOCER®层厚度的最佳剂量。成功制造了两种流体装置:定向润湿装置(流体二极管)和电泳芯片。流体二极管芯片的操作取决于尖角的几何形状和水接触角,并且两者均已成功定制以实现二位性。电泳芯片用于分离两种荧光染料,若丹明123和荧光素。电泳芯片也使用ORMOCER®到ORMOCER®的键合

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